Paper Highlights Experimental Modifications and Recommendations for Using An Alternative Testing Strategy for Nanomaterials

A review published in Archives of Toxicology this month evaluated the applicability of OECD Test Guideline 210 (Fish, Early-life Stages) to characterize the ecotoxicity of engineered nanomaterials. The authors exposed zebrafish embryos to titanium dioxide nanoparticles, silver nanoparticles and multi-walled carbon nanotubes following the protocol and noted several improvements to the essay to more effectively gauge the toxicity of these materials. Recommendations included:

  • conducting tests using exposure chambers that ensure mixing and proper dosing
  • using quantitative measurements for assessing hatching and morphometrics
  • conducting shorter, larvae-only toxicity tests with nanomaterials
Guidance, Nanomaterials, Risk AnalysisJames Edereview published in Archives of Toxicology, Archives of Toxicology, Vireo Advisors, oecd, OECD Test Guideline 210, Fish Early-life Stag, ecotoxicity, Nanomaterials, zebrafish, titanium dioxide nanoparticles, multi-walled carbon nanotubes, silver nanoparticles, toxicity, morphometricsComment